PittsburghV1, Main, Exploration, bibRecord, 002163

Meta-analysis of loci associated with age at natural menopause in African-American women

Identifieur interne : 002163 ( Main/Exploration ); précédent : 002162; suivant : 002164

Meta-analysis of loci associated with age at natural menopause in African-American women

Auteurs : Christina T. L. Chen [États-Unis] ; Ching-Ti Liu [États-Unis] ; Gary K. Chen ; Jeanette S. Andrews [États-Unis] ; Alice M. Arnold ; Jill Dreyfus [États-Unis] ; Nora Franceschini ; Melissa E. Garcia [États-Unis] ; Kathleen F. Kerr ; Guo Li [États-Unis] ; Kurt K. Lohman [États-Unis] ; Solomon K. Musani [États-Unis] ; Michael A. Nalls [États-Unis] ; Leslie J. Raffel ; Jennifer Smith [États-Unis] ; Christine B. Ambrosone [États-Unis] ; Elisa V. Bandera [États-Unis] ; Leslie Bernstein [États-Unis] ; Angela Britton [États-Unis] ; Robert G. Brzyski [États-Unis] ; Anne Cappola [États-Unis] ; Christopher S. Carlson [États-Unis] ; David Couper ; Sandra L. Deming [États-Unis] ; Mark O. Goodarzi [États-Unis] ; Gerardo Heiss ; Esther M. John [États-Unis] ; Xiaoning Lu [États-Unis] ; Loic Le Marchand [États-Unis] ; Kristin Marciante [États-Unis] ; Barbara Mcknight ; Robert Millikan [États-Unis] ; Nora L. Nock [États-Unis] ; Andrew F. Olshan [États-Unis] ; Michael F. Press [États-Unis] ; Dhananjay Vaiyda [États-Unis] ; Nancy F. Woods [États-Unis] ; Herman A. Taylor [États-Unis] ; Wei Zhao [États-Unis] ; Wei Zheng [États-Unis] ; Michele K. Evans ; Tamara B. Harris [États-Unis] ; Brian E. Henderson ; Sharon L. R. Kardia [États-Unis] ; Charles Kooperberg [États-Unis] ; Yongmei Liu [États-Unis] ; Thomas H. Mosley [États-Unis] ; Bruce Psaty [États-Unis] ; Melissa Wellons [États-Unis] ; Beverly G. Windham [États-Unis] ; Alan B. Zonderman [États-Unis] ; L. Adrienne Cupples [États-Unis] ; Ellen W. Demerath [États-Unis] ; Christopher Haiman ; Joanne M. Murabito [États-Unis] ; Aleksandar Rajkovic [États-Unis]

Source :

Human Molecular Genetics [ 0964-6906 ] ; 2014.

RBID : PMC:4030781

Descripteurs français

KwdFr :
- Afro-Américains (génétique), Chromosomes humains, Facteurs de l'âge, Femelle, Humains, Locus génétiques, Ménopause (ethnologie), Ménopause (génétique), Population d'origine européenne (génétique), Variation génétique, États-Unis d'Amérique, Étude d'association pangénomique.
MESH :
- ethnologie : Ménopause.
- génétique : Afro-Américains, Ménopause, Population d'origine européenne.
- Chromosomes humains, Facteurs de l'âge, Femelle, Humains, Locus génétiques, Variation génétique, États-Unis d'Amérique, Étude d'association pangénomique.
Wicri :
- geographic : États-Unis.

English descriptors

KwdEn :
- African Americans (genetics), Age Factors, Chromosomes, Human, European Continental Ancestry Group (genetics), Female, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Humans, Menopause (ethnology), Menopause (genetics), United States.
MESH :
- geographic : United States.
- ethnology : Menopause.
- genetics : African Americans, European Continental Ancestry Group, Menopause.
- Age Factors, Chromosomes, Human, Female, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Humans.

Abstract

Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030781

DOI: 10.1093/hmg/ddu041
PubMed: 24493794
PubMed Central: 4030781

Affiliations:

États-Unis

Le document en format XML

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<author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M." last="Arnold">Alice M. Arnold</name>
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<author><name sortKey="Kerr, Kathleen F" sort="Kerr, Kathleen F" uniqKey="Kerr K" first="Kathleen F." last="Kerr">Kathleen F. Kerr</name>
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<author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name>
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<author><name sortKey="Lohman, Kurt K" sort="Lohman, Kurt K" uniqKey="Lohman K" first="Kurt K." last="Lohman">Kurt K. Lohman</name>
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,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Musani, Solomon K" sort="Musani, Solomon K" uniqKey="Musani S" first="Solomon K." last="Musani">Solomon K. Musani</name>
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,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
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,<country>USA</country>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Raffel, Leslie J" sort="Raffel, Leslie J" uniqKey="Raffel L" first="Leslie J." last="Raffel">Leslie J. Raffel</name>
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</affiliation>
</author>
<author><name sortKey="Smith, Jennifer" sort="Smith, Jennifer" uniqKey="Smith J" first="Jennifer" last="Smith">Jennifer Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Cancer Prevention and Control</addr-line>
,<institution>Roswell Park Cancer Institute</institution>
,<addr-line>Buffalo, NY 14263</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Bandera, Elisa V" sort="Bandera, Elisa V" uniqKey="Bandera E" first="Elisa V." last="Bandera">Elisa V. Bandera</name>
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,<addr-line>New Brunswick, NJ 08903</addr-line>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Britton, Angela" sort="Britton, Angela" uniqKey="Britton A" first="Angela" last="Britton">Angela Britton</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Brzyski, Robert G" sort="Brzyski, Robert G" uniqKey="Brzyski R" first="Robert G." last="Brzyski">Robert G. Brzyski</name>
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,<institution>University of Texas Health Science Center</institution>
,<addr-line>San Antonio, TX 78229</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Cappola, Anne" sort="Cappola, Anne" uniqKey="Cappola A" first="Anne" last="Cappola">Anne Cappola</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine</addr-line>
,<institution>University of Pennsylvania</institution>
,<addr-line>Philadelphia, PA 19104</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name>
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,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Biostatistics, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Deming, Sandra L" sort="Deming, Sandra L" uniqKey="Deming S" first="Sandra L." last="Deming">Sandra L. Deming</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>
,<institution>Vanderbilt University School of Medicine</institution>
,<addr-line>Nashville, TN 37232</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goodarzi, Mark O" sort="Goodarzi, Mark O" uniqKey="Goodarzi M" first="Mark O." last="Goodarzi">Mark O. Goodarzi</name>
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,<institution>Cedars-Sinai Medical Center</institution>
,<addr-line>Los Angeles, CA 90048</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Heiss, Gerardo" sort="Heiss, Gerardo" uniqKey="Heiss G" first="Gerardo" last="Heiss">Gerardo Heiss</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
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,<institution>Stanford University School of Medicine</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lu, Xiaoning" sort="Lu, Xiaoning" uniqKey="Lu X" first="Xiaoning" last="Lu">Xiaoning Lu</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Biostatistics, School of Public Health</addr-line>
,<institution>Boston University</institution>
,<addr-line>Boston, MA 02118</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>Division of Clinical Informatics</addr-line>
,<institution>Beth Israel Deaconess Medical Center</institution>
,<addr-line>Boston, MA 02118</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
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,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marciante, Kristin" sort="Marciante, Kristin" uniqKey="Marciante K" first="Kristin" last="Marciante">Kristin Marciante</name>
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,<institution>University of Washington</institution>
,<addr-line>Seattle, WA 98195</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Millikan, Robert" sort="Millikan, Robert" uniqKey="Millikan R" first="Robert" last="Millikan">Robert Millikan</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Lineberger Comprehensive Cancer Center</addr-line>
,<institution>University of North Carolina</institution>
,<addr-line>Chapel Hill, NC 27514</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Nock, Nora L" sort="Nock, Nora L" uniqKey="Nock N" first="Nora L." last="Nock">Nora L. Nock</name>
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,<institution>Case Western University</institution>
,<addr-line>Cleveland, OH 44106</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Olshan, Andrew F" sort="Olshan, Andrew F" uniqKey="Olshan A" first="Andrew F." last="Olshan">Andrew F. Olshan</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Lineberger Comprehensive Cancer Center</addr-line>
,<institution>University of North Carolina</institution>
,<addr-line>Chapel Hill, NC 27514</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Press, Michael F" sort="Press, Michael F" uniqKey="Press M" first="Michael F." last="Press">Michael F. Press</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90089</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vaiyda, Dhananjay" sort="Vaiyda, Dhananjay" uniqKey="Vaiyda D" first="Dhananjay" last="Vaiyda">Dhananjay Vaiyda</name>
<affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Department of Medicine</addr-line>
,<institution>Johns Hopkins University</institution>
,<addr-line>Baltimore, MD 21287</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Woods, Nancy F" sort="Woods, Nancy F" uniqKey="Woods N" first="Nancy F." last="Woods">Nancy F. Woods</name>
<affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Biobehavioral Nursing and Health Systems</addr-line>
,<institution>University of Washington</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taylor, Herman A" sort="Taylor, Herman A" uniqKey="Taylor H" first="Herman A." last="Taylor">Herman A. Taylor</name>
<affiliation wicri:level="1"><nlm:aff id="af14"><institution>University of Mississippi Medical Center</institution>
,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>
,<institution>Vanderbilt University School of Medicine</institution>
,<addr-line>Nashville, TN 37232</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Evans, Michele K" sort="Evans, Michele K" uniqKey="Evans M" first="Michele K." last="Evans">Michele K. Evans</name>
<affiliation><nlm:aff id="af32"><addr-line>Health Disparities Research Section, Clinical Research Branch</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Clinical Research Branch</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Laboratory of Epidemiology and Population Sciences</addr-line>
,<institution>National Institute on Aging</institution>
,<addr-line>Bethesda, MD 20814</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Preventive Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Public Health Sciences</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Department of Epidemiology and Prevention, Division of Public Health Sciences</addr-line>
,<institution>Wake Forest University School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Division of Geriatric Medicine</addr-line>
,<institution>University of Mississippi Medical Center</institution>
,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Departments of Medicine, Epidemiology and Health Services</addr-line>
,<institution>University of Washington and Group Health Research Institute</institution>
,<addr-line>Seattle, WA</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wellons, Melissa" sort="Wellons, Melissa" uniqKey="Wellons M" first="Melissa" last="Wellons">Melissa Wellons</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>School of Medicine</addr-line>
,<institution>Vanderbilt University</institution>
,<addr-line>Nashville, TN 37240</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Windham, Beverly G" sort="Windham, Beverly G" uniqKey="Windham B" first="Beverly G." last="Windham">Beverly G. Windham</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Division of Geriatric Medicine</addr-line>
,<institution>University of Mississippi Medical Center</institution>
,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zonderman, Alan B" sort="Zonderman, Alan B" uniqKey="Zonderman A" first="Alan B." last="Zonderman">Alan B. Zonderman</name>
<affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Laboratory of Personality and Cognition</addr-line>
,<institution>National Institute on Aging, National Institutes of Health</institution>
,<addr-line>Baltimore, MD 21224</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Biostatistics, School of Public Health</addr-line>
,<institution>Boston University</institution>
,<addr-line>Boston, MA 02118</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart, Lung and Blood Institute's Framingham Heart Study</institution>
,<addr-line>Framingham, MA 01702</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Demerath, Ellen W" sort="Demerath, Ellen W" uniqKey="Demerath E" first="Ellen W." last="Demerath">Ellen W. Demerath</name>
<affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Division of Epidemiology and Community Health, School of Public Health</addr-line>
,<institution>University of Minnesota</institution>
,<addr-line>Minneapolis, MN 55455</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher" sort="Haiman, Christopher" uniqKey="Haiman C" first="Christopher" last="Haiman">Christopher Haiman</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Preventive Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M." last="Murabito">Joanne M. Murabito</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart, Lung and Blood Institute's Framingham Heart Study</institution>
,<addr-line>Framingham, MA 01702</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Medicine, Section of General Internal Medicine</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rajkovic, Aleksandar" sort="Rajkovic, Aleksandar" uniqKey="Rajkovic A" first="Aleksandar" last="Rajkovic">Aleksandar Rajkovic</name>
<affiliation wicri:level="1"><nlm:aff id="af38"><addr-line>Department of Obstetrics, Gynecology and Reproductive Science</addr-line>
,<institution>University of Pittsburgh</institution>
,<addr-line>Pittsburgh, PA 15213</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24493794</idno>
<idno type="pmc">4030781</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030781</idno>
<idno type="RBID">PMC:4030781</idno>
<idno type="doi">10.1093/hmg/ddu041</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000946</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000946</idno>
<idno type="wicri:Area/Pmc/Curation">000922</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000922</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D06</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D06</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002A32</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A32</idno>
<idno type="wicri:Area/PubMed/Curation">002A19</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A19</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002A19</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A19</idno>
<idno type="wicri:Area/Ncbi/Merge">000F53</idno>
<idno type="wicri:Area/Ncbi/Curation">000F53</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F53</idno>
<idno type="wicri:doubleKey">0964-6906:2014:Chen C:meta:analysis:of</idno>
<idno type="wicri:Area/Main/Merge">002251</idno>
<idno type="wicri:Area/Main/Curation">002163</idno>
<idno type="wicri:Area/Main/Exploration">002163</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis of loci associated with age at natural menopause in African-American women</title>
<author><name sortKey="Chen, Christina T L" sort="Chen, Christina T L" uniqKey="Chen C" first="Christina T. L." last="Chen">Christina T. L. Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Public Health Sciences</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Biostatistics, School of Public Health</addr-line>
,<institution>Boston University</institution>
,<addr-line>Boston, MA 02118</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart, Lung and Blood Institute's Framingham Heart Study</institution>
,<addr-line>Framingham, MA 01702</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Gary K" sort="Chen, Gary K" uniqKey="Chen G" first="Gary K." last="Chen">Gary K. Chen</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Preventive Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Biostatistical Sciences, Division of Public Health Sciences</addr-line>
,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M." last="Arnold">Alice M. Arnold</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dreyfus, Jill" sort="Dreyfus, Jill" uniqKey="Dreyfus J" first="Jill" last="Dreyfus">Jill Dreyfus</name>
<affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Division of Epidemiology and Community Health, School of Public Health</addr-line>
,<institution>University of Minnesota</institution>
,<addr-line>Minneapolis, MN 55455</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Franceschini, Nora" sort="Franceschini, Nora" uniqKey="Franceschini N" first="Nora" last="Franceschini">Nora Franceschini</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Garcia, Melissa E" sort="Garcia, Melissa E" uniqKey="Garcia M" first="Melissa E." last="Garcia">Melissa E. Garcia</name>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Laboratory of Epidemiology and Population Sciences</addr-line>
,<institution>National Institute on Aging</institution>
,<addr-line>Bethesda, MD 20814</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kerr, Kathleen F" sort="Kerr, Kathleen F" uniqKey="Kerr K" first="Kathleen F." last="Kerr">Kathleen F. Kerr</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Medicine</addr-line>
,<institution>University of Washington</institution>
,<addr-line>Seattle, WA 98195</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lohman, Kurt K" sort="Lohman, Kurt K" uniqKey="Lohman K" first="Kurt K." last="Lohman">Kurt K. Lohman</name>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Department of Biostatistical Sciences, Division of Public Health Sciences</addr-line>
,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Musani, Solomon K" sort="Musani, Solomon K" uniqKey="Musani S" first="Solomon K." last="Musani">Solomon K. Musani</name>
<affiliation wicri:level="1"><nlm:aff id="af14"><institution>University of Mississippi Medical Center</institution>
,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>Laboratory of Neurogenetics,</addr-line>
<institution>National Institute on Aging, National Institutes of Health</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raffel, Leslie J" sort="Raffel, Leslie J" uniqKey="Raffel L" first="Leslie J." last="Raffel">Leslie J. Raffel</name>
<affiliation><nlm:aff id="af17"><addr-line>Department of Pediatrics and Biomedical Sciences</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Jennifer" sort="Smith, Jennifer" uniqKey="Smith J" first="Jennifer" last="Smith">Jennifer Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Cancer Prevention and Control</addr-line>
,<institution>Roswell Park Cancer Institute</institution>
,<addr-line>Buffalo, NY 14263</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bandera, Elisa V" sort="Bandera, Elisa V" uniqKey="Bandera E" first="Elisa V." last="Bandera">Elisa V. Bandera</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>The Cancer Institute of New Jersey</institution>
,<addr-line>New Brunswick, NJ 08903</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name>
<affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Division of Cancer Etiology, Department of Population Science</addr-line>
,<institution>Beckman Research Institute</institution>
,<addr-line>City of Hope, Duarte, CA 91010</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Britton, Angela" sort="Britton, Angela" uniqKey="Britton A" first="Angela" last="Britton">Angela Britton</name>
<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>Laboratory of Neurogenetics,</addr-line>
<institution>National Institute on Aging, National Institutes of Health</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brzyski, Robert G" sort="Brzyski, Robert G" uniqKey="Brzyski R" first="Robert G." last="Brzyski">Robert G. Brzyski</name>
<affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Obstetrics and Gynecology</addr-line>
,<institution>University of Texas Health Science Center</institution>
,<addr-line>San Antonio, TX 78229</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cappola, Anne" sort="Cappola, Anne" uniqKey="Cappola A" first="Anne" last="Cappola">Anne Cappola</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine</addr-line>
,<institution>University of Pennsylvania</institution>
,<addr-line>Philadelphia, PA 19104</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S." last="Carlson">Christopher S. Carlson</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Public Health Sciences</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couper, David" sort="Couper, David" uniqKey="Couper D" first="David" last="Couper">David Couper</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Biostatistics, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Deming, Sandra L" sort="Deming, Sandra L" uniqKey="Deming S" first="Sandra L." last="Deming">Sandra L. Deming</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>
,<institution>Vanderbilt University School of Medicine</institution>
,<addr-line>Nashville, TN 37232</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goodarzi, Mark O" sort="Goodarzi, Mark O" uniqKey="Goodarzi M" first="Mark O." last="Goodarzi">Mark O. Goodarzi</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Division of Endocrinology, Diabetes, and Metabolism</addr-line>
,<institution>Cedars-Sinai Medical Center</institution>
,<addr-line>Los Angeles, CA 90048</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heiss, Gerardo" sort="Heiss, Gerardo" uniqKey="Heiss G" first="Gerardo" last="Heiss">Gerardo Heiss</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Division of Epidemiology, Department of Health Research & Policy</addr-line>
,<institution>Stanford University School of Medicine</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lu, Xiaoning" sort="Lu, Xiaoning" uniqKey="Lu X" first="Xiaoning" last="Lu">Xiaoning Lu</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Biostatistics, School of Public Health</addr-line>
,<institution>Boston University</institution>
,<addr-line>Boston, MA 02118</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>Division of Clinical Informatics</addr-line>
,<institution>Beth Israel Deaconess Medical Center</institution>
,<addr-line>Boston, MA 02118</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Epidemiology Program, Cancer Research Center</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marciante, Kristin" sort="Marciante, Kristin" uniqKey="Marciante K" first="Kristin" last="Marciante">Kristin Marciante</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Medicine</addr-line>
,<institution>University of Washington</institution>
,<addr-line>Seattle, WA 98195</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Biostatistics</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Millikan, Robert" sort="Millikan, Robert" uniqKey="Millikan R" first="Robert" last="Millikan">Robert Millikan</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Lineberger Comprehensive Cancer Center</addr-line>
,<institution>University of North Carolina</institution>
,<addr-line>Chapel Hill, NC 27514</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nock, Nora L" sort="Nock, Nora L" uniqKey="Nock N" first="Nora L." last="Nock">Nora L. Nock</name>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Department of Epidemiology and Biostatistics</addr-line>
,<institution>Case Western University</institution>
,<addr-line>Cleveland, OH 44106</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olshan, Andrew F" sort="Olshan, Andrew F" uniqKey="Olshan A" first="Andrew F." last="Olshan">Andrew F. Olshan</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Epidemiology, Gillings School of Global Public Health</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Gillings School of Global Public Health</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Lineberger Comprehensive Cancer Center</addr-line>
,<institution>University of North Carolina</institution>
,<addr-line>Chapel Hill, NC 27514</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Press, Michael F" sort="Press, Michael F" uniqKey="Press M" first="Michael F." last="Press">Michael F. Press</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90089</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vaiyda, Dhananjay" sort="Vaiyda, Dhananjay" uniqKey="Vaiyda D" first="Dhananjay" last="Vaiyda">Dhananjay Vaiyda</name>
<affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Department of Medicine</addr-line>
,<institution>Johns Hopkins University</institution>
,<addr-line>Baltimore, MD 21287</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Woods, Nancy F" sort="Woods, Nancy F" uniqKey="Woods N" first="Nancy F." last="Woods">Nancy F. Woods</name>
<affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Biobehavioral Nursing and Health Systems</addr-line>
,<institution>University of Washington</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taylor, Herman A" sort="Taylor, Herman A" uniqKey="Taylor H" first="Herman A." last="Taylor">Herman A. Taylor</name>
<affiliation wicri:level="1"><nlm:aff id="af14"><institution>University of Mississippi Medical Center</institution>
,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Division of Epidemiology, Department of Medicine</addr-line>
,<institution>Vanderbilt University School of Medicine</institution>
,<addr-line>Nashville, TN 37232</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Evans, Michele K" sort="Evans, Michele K" uniqKey="Evans M" first="Michele K." last="Evans">Michele K. Evans</name>
<affiliation><nlm:aff id="af32"><addr-line>Health Disparities Research Section, Clinical Research Branch</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">Clinical Research Branch</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Laboratory of Epidemiology and Population Sciences</addr-line>
,<institution>National Institute on Aging</institution>
,<addr-line>Bethesda, MD 20814</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Preventive Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Epidemiology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Public Health Sciences</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Department of Epidemiology and Prevention, Division of Public Health Sciences</addr-line>
,<institution>Wake Forest University School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Division of Geriatric Medicine</addr-line>
,<institution>University of Mississippi Medical Center</institution>
,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Departments of Medicine, Epidemiology and Health Services</addr-line>
,<institution>University of Washington and Group Health Research Institute</institution>
,<addr-line>Seattle, WA</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wellons, Melissa" sort="Wellons, Melissa" uniqKey="Wellons M" first="Melissa" last="Wellons">Melissa Wellons</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>School of Medicine</addr-line>
,<institution>Vanderbilt University</institution>
,<addr-line>Nashville, TN 37240</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Windham, Beverly G" sort="Windham, Beverly G" uniqKey="Windham B" first="Beverly G." last="Windham">Beverly G. Windham</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Division of Geriatric Medicine</addr-line>
,<institution>University of Mississippi Medical Center</institution>
,<addr-line>Jackson, MS 39216</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zonderman, Alan B" sort="Zonderman, Alan B" uniqKey="Zonderman A" first="Alan B." last="Zonderman">Alan B. Zonderman</name>
<affiliation wicri:level="1"><nlm:aff id="af33"><addr-line>Laboratory of Personality and Cognition</addr-line>
,<institution>National Institute on Aging, National Institutes of Health</institution>
,<addr-line>Baltimore, MD 21224</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Biostatistics, School of Public Health</addr-line>
,<institution>Boston University</institution>
,<addr-line>Boston, MA 02118</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart, Lung and Blood Institute's Framingham Heart Study</institution>
,<addr-line>Framingham, MA 01702</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Demerath, Ellen W" sort="Demerath, Ellen W" uniqKey="Demerath E" first="Ellen W." last="Demerath">Ellen W. Demerath</name>
<affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Division of Epidemiology and Community Health, School of Public Health</addr-line>
,<institution>University of Minnesota</institution>
,<addr-line>Minneapolis, MN 55455</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher" sort="Haiman, Christopher" uniqKey="Haiman C" first="Christopher" last="Haiman">Christopher Haiman</name>
<affiliation><nlm:aff id="af4"><addr-line>Department of Preventive Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Murabito, Joanne M" sort="Murabito, Joanne M" uniqKey="Murabito J" first="Joanne M." last="Murabito">Joanne M. Murabito</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart, Lung and Blood Institute's Framingham Heart Study</institution>
,<addr-line>Framingham, MA 01702</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>Department of Medicine, Section of General Internal Medicine</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>Boston, MA</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rajkovic, Aleksandar" sort="Rajkovic, Aleksandar" uniqKey="Rajkovic A" first="Aleksandar" last="Rajkovic">Aleksandar Rajkovic</name>
<affiliation wicri:level="1"><nlm:aff id="af38"><addr-line>Department of Obstetrics, Gynecology and Reproductive Science</addr-line>
,<institution>University of Pittsburgh</institution>
,<addr-line>Pittsburgh, PA 15213</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Molecular Genetics</title>
<idno type="ISSN">0964-6906</idno>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African Americans (genetics)</term>
<term>Age Factors</term>
<term>Chromosomes, Human</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Female</term>
<term>Genetic Loci</term>
<term>Genetic Variation</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Menopause (ethnology)</term>
<term>Menopause (genetics)</term>
<term>United States</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Afro-Américains (génétique)</term>
<term>Chromosomes humains</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Locus génétiques</term>
<term>Ménopause (ethnologie)</term>
<term>Ménopause (génétique)</term>
<term>Population d'origine européenne (génétique)</term>
<term>Variation génétique</term>
<term>États-Unis d'Amérique</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Ménopause</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Menopause</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>African Americans</term>
<term>European Continental Ancestry Group</term>
<term>Menopause</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Afro-Américains</term>
<term>Ménopause</term>
<term>Population d'origine européenne</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Chromosomes, Human</term>
<term>Female</term>
<term>Genetic Loci</term>
<term>Genetic Variation</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Chromosomes humains</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Locus génétiques</term>
<term>Variation génétique</term>
<term>États-Unis d'Amérique</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (<italic>P</italic>
-value < 0.05): <italic>AMHR2</italic>
, <italic>RHBLD2</italic>
, <italic>PRIM1</italic>
, <italic>HK3/UMC1</italic>
, <italic>BRSK1/TMEM150B</italic>
 and <italic>MCM8</italic>
. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
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<name sortKey="Evans, Michele K" sort="Evans, Michele K" uniqKey="Evans M" first="Michele K." last="Evans">Michele K. Evans</name>
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<name sortKey="Haiman, Christopher" sort="Haiman, Christopher" uniqKey="Haiman C" first="Christopher" last="Haiman">Christopher Haiman</name>
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<name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
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<name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name>
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<name sortKey="Lu, Xiaoning" sort="Lu, Xiaoning" uniqKey="Lu X" first="Xiaoning" last="Lu">Xiaoning Lu</name>
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<name sortKey="Vaiyda, Dhananjay" sort="Vaiyda, Dhananjay" uniqKey="Vaiyda D" first="Dhananjay" last="Vaiyda">Dhananjay Vaiyda</name>
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<name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name>
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</record>

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Meta-analysis of loci associated with age at natural menopause in African-American women

Meta-analysis of loci associated with age at natural menopause in African-American women

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